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SAM-e
SAMe is an important physiological agent synthesized by the body. SAMe is involved in over 40 biochemical reactions in the body. In fact, SAMe is found in every living organism.
S-adenosylmethionine (SAM-E) is an amino acid that is used in the treatment of many conditions including depression, liver disease, osteoarthritis, fibromyalgia, schizophrenia, migraine headaches, and to increase bile flow. Other names for SAM-E include: S-Adensyl Methionine, L-Methionine, Adomet, and Ademethionine.
Over 150,000 Americans and many thousands of Europeans use SAM-E supplements regularly. SAM-E was discovered in Italy about 5 decades ago (Cantoni, 1952). However, the first clinical study of SAM-E's use for depression was not completed until the 1970s (Agnoli et al., 1976). At that time there were no usable oral preparations and early studies had to use intravenous [IV] and intramuscular [IM] delivery. SAM-E was first introduced into the U.S. dietary supplement market in 1999. It has been used with success to treat depression in Europe for the past 20 years.
SAM-E (also known as SAM or AdoMet) is a derivative of the amino acid, methionine. It's formed when methionine combines with adenosine triphosphate (ATP), a nucleotide present in all living cells. ATP is the major source of cellular energy. The liver uses this process to make SAM-E, as much as 8 grams of it every day, when the liver is perfectly healthy. Liver disease, osteoarthritis and the overuse of prescription drugs or over-the-counter medications can diminish the body's production of SAM-E. A small amount of SAM-E is found in food, but it is highly unstable and an unreliable means of increasing blood levels.
As a methyl donor, SAM-E "donates" units called methyl groups, which contain hydrogen and carbon atoms, to other substances. This process is called methylation, and it is one way in which the body protects itself from damage on the cellular level.
SAM e and Emotional Well Being
SAM-e is essential to the manufacture of important brain compounds such as neurotransmitters and phospholipids. Supplementing the diet with SAMe can result in an increase in the levels of serotonin and phosphatidylserine which can enhance mood and emotional well being.
SAMe and Healthy Liver Function
SAMe is involved in many liver processes. Supplementation with SAMe can help increase levels of glutathione in the liver, thereby promoting healthy liver function.
SAM e and Joint Health
Clinical studies indicate that supplementation of SAMe is capable of improving the structure and function of joint cartilage. SAMe has also been shown to actually increase cartilage formation. These effects can enhance joint health and mobility.
SAM-E facilitates the manufacture of brain neurotransmitters
Methyl donors help to protect against cancer, heart disease, neurological disorders, and many age-related problems, and facilitate the manufacture of DNA and brain neurotransmitters. SAM-E is involved in more than 50 methylation reactions in the body, including the regulation of various hormones and neurotransmitters such as serotonin, melatonin, and dopamine.
Once SAM-E donates its methyl group to choline, creatine, carnitine, DNA, RNA, epinephrine, and other compounds, it is transformed into S-adenosyl-homocysteine, (SAH). SAH donates its sulfur molecule to sulfur-containing amino acids such as cysteine, from which glutathione is formed. SAH then gives up its adenosine molecule to yield homocysteine. Homocysteine is a potentially toxic amino acid and an independent risk factor for coronary disease. Folic acid, choline, or betaine can change homocysteine back to methionine in the presence of vitamin B12, or convert homocysteine into cysteine and glutathione in the presence of vitamin B6. For this reason, it is recommended to supplement your diet with vitamin B12 and B6 when taking SAM-E.
SAM-E is particularly important for the liver because glutathione is synthesized from it. Glutathione is crucial for liver function. A good portion of liver SAM-E is turned into glutathione. Glutathione is the liver's natural antioxidant.
SAM-E has many other beneficial uses for several wide-ranging conditions.
SAM e can boast these facts:
SAM-e time proven by over twenty years of research
SAM e rated for more than 2 years of stability
SAM-e produced containing a FULL 200 mg or 400 mg of active SAM-e
SAM e certified by Star K to be Kosher
SAM-e Enteric Coated
SAM e animal byproduct free
Symptoms of depression include:
Persistent feelings of sadness or emptiness.
Feelings of helplessness, hopelessness, guilt, and worthlessness.
Loss of interest in pleasurable activities, including sex.
Sleep disturbances.
Fatigue.
Loss of energy or enthusiasm.
Difficulty in concentrating or making decisions.
Ongoing physical symptoms, such as headaches or digestive disorders, that don't respond to treatment.
Crying, tearfulness.
Poor appetite with weight loss, or overeating and weight gain.
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