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Pantethine
Pantethine is a combination of the vitamin pantothenic acid and the low-molecular-weight aminothiol cysteamine. Pantethine is the biologically active form of pantothenic acid (vitamin B5).
Pantethine lowers cholesterol and other lipid levels. Research indicates that pantethine supplements are helpful in reducing total cholesterol, LDL cholesterol, and triglyceride levels while at the same time raising the good HDL cholesterol in the body. High levels of LDL (low-density lipoprotein) - the "bad cholesterol" - is a major contributing factor of heart disease. The cholesterol forms plaque in the heart's blood vessels, which restricts or blocks the supply of blood to the heart, and causes a condition called atherosclerosis, which is a buildup of fatty substances in the inner layers of the arteries.
Pantethine may be a good cholesterol-lowering alternative for people with diabetes, who cannot take niacin due to the potential side effects on blood sugar regulation.
What is Pantethine?
Pantethine is the active form of pantothenic acid. It has been shown to significantly reduce serum triglycerides, total cholesterol, and LDL-cholesterol (the so-called "bad cholesterol") levels while increasing HDL ("good cholestrerol") levels in several clinical trials. Pantethine has the advantage of being an effective treatment for high cholesterol while avoiding the undesirable side effects of synthetic lipid-lowering drugs. In fact, there appear to be no toxicity or side effects from to pantethine, making an attractive and natural treatment alternative. Pantethine has been used for the past 30 years in Japan, where it is approved as a pharmaceutical agent for the purpose of increasing HDL-C, the "good cholesterol" needed by the body to maintain a healthy heart.
A naturally occurring substance, Pantethine is produced as a byproduct when the body metabolizes pantothenic acid. The name "pantothenic," from which the word "pantethine" is drawn, literally means "something that is found everywhere." It may not be literally everywhere, but pantethine and pantothenic acid are found in most foods, including vegetables, dairy, eggs, grains, and meat. Liver, salmon and yeast have especially high concentrations of pantothenic acid, which the body uses to produce pantethine.
Although Pantethine is derived from pantothenic acid, pantethine is not the same as pantothenic acid, and it is important to remember that the two substances are not interchangeable. Structurally, pantethine is a more stable disulfide form (or a double bond) of pantothenic acid. It is also a more active metabolic substrate that is converted into an enzyme called "Co-Enzyme A," or simply, "CoA." CoA plays a critical role in the metabolism and breakdown of the three essential micronutrients namely proteins, carbohydrates and fats.
Pantothenic acid has its own benefits, including enhanced adrenal functions and the reduction of hypertension, or high blood pressure. Pantothenic acid is also known as vitamin B5, and is a member of the water-soluble B vitamin family. It is an essential ingredient of two substances, coenzyme A and acyl carrier protein, which are needed to metabolize carbohydrates and fats. The same coenzymes play a part in production of certain hormones, vitamin D, red blood cells, and the neurotransmitter acetylcholine. Pantothenic acid is necessary for proper growth and development.
Both pantothenic acid as well as pantethine should be considered as one synergistic unit and not as mutually exclusive nutrients. Supplements of the two nutrients can be taken together for maximum benefits.
Pantethine Benefits
Pantethine lowers cholesterol and other lipid levels
Pantethine may be a good cholesterol-lowering alternative for people with diabetes, who cannot take niacin due to the potential side effects on blood sugar regulation.
Pantethine may lower triglyceride levels
Pantethine may improve symptoms associated with having a fatty liver.
Pantethine has been shown to enhance cognitive abilities.
Other possible uses:
Pantethine may help rheumatoid arthritis .Pantethine has also been used successfully by some doctors for patients who experience heart burn, ulcers and candida infections and has been used with some success in the management of certain allergies.
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Pantethine
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