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Resveratrol
Resveratrol is a natural antioxidant found in red wine. Antioxidants protect cells in the body from damage by free radicals, naturally occurring but harmful substances that are thought to play a role in cardiovascular disease. Resveratrol is also a phytoestrogen, a substance that mimics some of the effects of estrogen, while blocking others. Soy, another phytoestrogen, is thought to help prevent heart disease as well as cancer, and resveratrol might have similar effects. However, as yet none of these potential benefits of resveratrol have been documented in any meaningful way, and there is some evidence that resveratrol taken by mouth is broken down before it enters the bloodstream.
You may have heard of the "French paradox." The French diet is very high in saturated fat and cholesterol (just think of pate de fois gras and croissants), yet France has one of the world's lowest rates of heart disease. One theory for this apparent discrepancy is that another major player in the French diet—red wine—protects the arteries of the heart. (Another possibility, perhaps even more likely, is that cutting down on saturated fat is less harmful than previously thought.)
Resveratrol is not an essential nutrient. It is found in red wine as well as in red grape skins and seeds and purple grape juice. Peanuts also contain a small amount of resveratrol. Resveratrol supplements are available as well.
Therapeutic Dosages
Because there havent been any clinical studies, the optimal therapeutic dosage hasnt been established for resveratrol. Based on animal studies, a reasonable therapeutic dosage of resveratrol might be about 500 mg daily.
Therapeutic Uses
Very preliminary evidence such as the results of test tube studies suggests that resveratrol may help prevent heart disease,and cancer. However, not all studies have been favorable. Furthermore, there is some evidence that resveratrol is immediately broken down by the human liver, and thereby does not in fact enter the blood stream at any significant level. In any case, only double-blind studies can prove a treatment effective, and none have been reported with resveratrol.
Safety Issues
Resveratrol has a chemical structure similar to that of the synthetic estrogenic hormone diethylstilbestrol and it has estrogenic effects. According to one study, it might stimulate the growth of breast cancer cells. For this reason, resveratrol should be avoided by women who have had breast cancer or are at high risk of developing it. Maximum safe dosages for children, pregnant or nursing women, or those with severe liver or kidney disease have not been determined.
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*These statements about Resveratrol have not been evaluated by the Food and Drug Administration. Resveratrol is not intended to diagnose, treat, cure, or prevent any disease.
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Resveratrol
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